The reservation is located off of Rte 146, exit 6 in south central Massachusetts.

From the East/West/Boston/Southeast:

Take MASS PIKE (Rte. I-90) to exit #10A in Millbury, rte 146 South.
Take Rte 146 South to exit # 6 in Sutton, Purgatory Rd.
Take a right onto Purgatory Rd.
Reservation entrance & visitor center is 1,000 feet on your right.

From Northeast/Worcester:

Take Rte 495 to Rte 290 West towards Worcester.
Take exit #12 and follow Rte 146S to Exit #6 in Sutton.
Take a right onto Purgatory Rd., following signs.
Reservation entrance & visitor center is 1,000 feet on your right.

From Northwest:

Take Rte 2 East to exit #33 in Leominster, rte 190 south.
Take Rte 190S to end, onto Rte 290 West in Worcester.
Follow Rte 290 West to exit #12, Rte 146 south.
Follow Rte 146S to Exit #6 in Sutton, Purgatory Rd.
Take a right onto Purgatory Rd., following signs.
Reservation entrance & visitor center is 1,000 feet on your right.