Return to Standards Table

trans-1,2-DICHLOROETHYLENE
CASRN: 156605

Update: August 1993

Current Massachusetts Regulatory Limit
MMCL = 0.1 mg/L. ORS has adopted the MCL issued by the U.S. EPA as part of the Phase II rule. (56 FR 3526; 1-30-91) 

Federal Regulatory Limit
The MCL for trans-1,2-dichloroethylene is equal to its MCLG of 0.1 mg/L. 

Basis for Criteria
The MCL is equal to the MCLG of 0.1 mg/L, which was derived based on hepatic toxicity reported from compound-specific data. The MCLG was derived using the RfD presented below and assuming that a 70 kg adult ingests 2 L/day of water. A relative source contribution factor of 20% was incorporated into this value.

RfD: 2 x 10-2 mg/kg/day
UF: 1000 (10 = interspecies; 10 = intraspecies; 10 = subchronic to chronic)
MF: 1

(US EPA, 1989)

Critical Effects
CD-1 mice were given trans-1,2-dichloroethylene for 90 days in drinking water. Significant increases in serum alkaline phosphatase were noted at the two highest dose in male mice. A NOAEL of 17 mg/kg/d was identified in male mice(1) based on normal serum chemistry values. 

Cancer Assessment
This chemical has been classified under U.S. EPA’s Group D, not classifiable as to human carcinogenicity. 

Class
VOC

Analytical Information
PQL
: 0.005 mg/L

Analytical Methods
U.S. EPA Methods 503.1 (purge and trap GC)
524 (purge and trap GC/MS)

PQLs and analytical methods may have been updated since this guidance value was last revised. Updated analytical methods for drinking water and their associated PQLs may be found at http://www.epa.gov/safewater/methods/methods.html

Other Regulatory Data
Any Health Advisories, Reference Doses (RfDs), cancer assessments or Cancer Potency Factors (CPFs) referenced in this document pertain to the derivation of the current guidance value. Updated information may be obtained from the following sources:

Health Advisories - The U.S. EPA provides guidance for shorter-term exposures for chemicals based on their non-cancer effects. Current health advisories may be more current than those used to derive MCLs and may be found at http://www.epa.gov/waterscience/drinking/standards/dwstandards.pdf

RfDs, cancer assessments and CPFs - For specific information pertaining to derivation of drinking water criteria, consult the Federal Register notice that announces the availability of the most current guidance for that chemical. In addition, information on other current RfDs and CPFs as well as cancer assessments for specific chemicals may be found in the U.S. EPA Integrated Risk Information System (IRIS) at http://www.epa.gov/iris/. Please note that the information in IRIS may differ from that used in the derivation process as published in the Federal Register notice.

References
Barnes, D.W., VM. Sanders, K.L. White, Jr., G.M. Shopp and A.E. Munson. 1985. Toxicology of trans-1,2-dichloroethylene in the mouse. Chem. Toxicol. 8:373-392.

Federal Register. May 22, 1989. Part II. Environmental Protection Agency. 40 CFR Parts 141, 142 and 143. National Primary and Secondary Drinking Water Regulations; Proposed Rule.

Federal Register. January 30, 1991. Part II. Environmental Protection Agency. 40 CFR Parts 141, 142, and 143. National Primary Drinking Water Regulations; Final Rule. (56 FR 3526).

U.S. EPA (U.S. Environmental Protection Agency). IRIS (Integrated Risk Information System). U.S. Environmental Protection Agency. Washington, D.C.. http://cfpub.epa.gov/ncea/iris/index.cfm