1,1,2-TRICHLORO-1,2,2-TRIFLUORO-ETHANE (Freon 113)
Update: March 1996
Current Massachusetts Regulatory Limit
ORSGL = 210 mg/L
Federal Regulatory Limit
The U.S. EPA has not published an MCL for 1,1,2-trichloro-1,2,2-trifluoroethane.
Basis for Criteria
The ORSGL is derived based on the RfD presented below and assumes that a 70 kg adult ingests 2 L/day of drinking water. A relative source contribution factor of 20% is incorporated into the final value.
RfD: 30 mg/kg/day (U.S. EPA, 1996)
UF: 10 MF: 1
In male volunteers acutely exposed for 2.75 hours to 19,161 mg/m3, slight impairment of psychomotor function was noted (Stopps and McLaughlin, 1967). In humans occupationally exposed by inhalation to 500 mg/m3 for 11 years or 5358 mg/m3 for 2.77 years, no apparent adverse effects were noted (Imbus and Adkins, 1972). The NOAEL of 5358 mg/m3 identified from this study was converted to an oral dose and used as the basis for the oral RfD presented above. The confidence in the RfD is low because the route of exposure in the study is inhalation not ingestion.
The U.S. EPA has not evaluated this chemical for carcinogenicity.
PQL: 0.01 mg/L
U.S. EPA 524.2; GC-MS
PQLs and analytical methods may have been updated since this guidance value was last revised. Updated analytical methods for drinking water and their associated PQLs may be found at http://www.epa.gov/safewater/methods/methods.html.
Other Regulatory Data
Any Health Advisories, Reference Doses (RfDs), cancer assessments or Cancer Potency Factors (CPFs) referenced in this document pertain to the derivation of the current guidance value. Updated information may be obtained from the following sources:
Health Advisories - The U.S. EPA provides guidance for shorter-term exposures for chemicals based on their non-cancer effects. Current health advisories may be more current than those used to derive MCLs and may be found at http://www.epa.gov/safewater/methods/methods.html.
RfDs, cancer assessments and CPFs - For specific information pertaining to derivation of drinking water criteria, consult the Federal Register notice that announces the availability of the most current guidance for that chemical. In addition, information on other current RfDs and CPFs as well as cancer assessments for specific chemicals may be found in the U.S. EPA Integrated Risk Information System (IRIS) at http://www.epa.gov/iris/. Please note that the information in IRIS may differ from that used in the derivation process as published in the Federal Register notice.
Imbus, H.R., and C. Adkins. 1972. Physical examination of workers exposed to trichlorotrifluoroethane. Arch. Environ. Health. 24(4): 257-261.
Stopps, G.J. and M. McLaughlin. 1967. Psychophysiological testing of human subjects exposed to solvent vapors. Amer. Ind. Hyg. Assoc. J. 28: 43-50.
U.S. EPA (U.S. Environmental Protection Agency). 1996. Integrated Risk Information System (IRIS). U.S. Environmental Protection Agency. Washington, D.C. http://cfpub.epa.gov/ncea/iris/index.cfm.
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