DI(2-ETHYLHEXYL) PHTHALATE (DEHP)
Update: August 1993
Current Massachusetts Regulatory Limit
MMCL = 0.006 mg/L. ORS has adopted the MCL published by the U.S. EPA (55 FR 30370 (7/25/90)).
Federal Regulatory Limit
The MCLG for DEHP is zero, based on its classification as a B2 carcinogen. The MCL of 0.006 mg/L is based on the PQL for DEHP.
Basis for Criteria
An MCLG of zero is assigned for DEHP based on carcinogenic effects. The MCL is based on the DEHP PQL. The U.S. EPA has set the PQL for DEHP at ten times its Method Detection Limit (MDL).
Toxic effects associated with subchronic and chronic exposure include hepatoxicity and testicular toxicity.
DEHP is classified as a group B2, probable human carcinogen. Increases in relative liver weights were observed in groups of treated females (64 and 19 mg/kg/day).
Orally administered DEHP produced significant dose-related increase in liver tumor responses in rats and mice of both sexes (NTP, 1992). The concentration associated with a 1 x 10-4 Excess Lifetime Cancer Risk (ELCR) is 0.4 mg/L (57 FR 31776 (7/17/92).
PQL: 0.005 mg/L
U.S. EPA 502.2 GC
PQLs and analytical methods may have been updated since this guidance value was last revised. Updated analytical methods for drinking water and their associated PQLs may be found at http://www.epa.gov/safewater/methods/methods.html.
Other Regulatory Data
Any Health Advisories, Reference Doses (RfDs), cancer assessments or Cancer Potency Factors (CPFs) referenced in this document pertain to the derivation of the current guidance value. Updated information may be obtained from the following sources:
Health Advisories - The U.S. EPA provides guidance for shorter-term exposures for chemicals based on their non-cancer effects. Current health advisories may be more current than those used to derive MCLs and may be found at http://www.epa.gov/waterscience/drinking/standards/dwstandards.pdf.
RfDs, cancer assessments and CPFs - For specific information pertaining to derivation of drinking water criteria, consult the Federal Register notice that announces the availability of the most current guidance for that chemical. In addition, information on other current RfDs and CPFs as well as cancer assessments for specific chemicals may be found in the U.S. EPA Integrated Risk Information System (IRIS) at http://www.epa.gov/iris/. Please note that the information in IRIS may differ from that used in the derivation process as published in the Federal Register notice.
Carpenter, C.P., C.S. West and H.F. Smyth. 1953. Chronic oral toxicity of di(ethylhexyl)phthalate for rats and guinea pigs. Arch. Indust. Hyd. Occup. Med 8:219-226.
Federal Register. July 25, 1990. Part II. Environmental Protection Agency. 40 CFR Part 141 et al. National Primary and Secondary Drinking Water Regulations; Synthetic Organic Chemicals and Inorganic Chemicals; Proposed Rule. (55 FR 30370)
Federal Register. July 17, 1992. Part III. Environmental Protection Agency. 40 CFR Parts 141 and 142. National Primary Drinking Water Regulations; Synthetic Organic Chemicals and Inorganic Chemicals; Final Rule. (57 FR 31776).
NTP. (National Toxicology Program) 1992. Carcinogenesis bioassay of di(2-ethylhexyl) phthalate (CAS no. 117-81-7) in F344 rats and B6C3F1 mice (feed study).NTP Technical Rep. Ser. TR No. 217, Research T.P., NC.
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