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ETHYLENE GLYCOL 
CASRN: 107211

Update: August 1993

Current Massachusetts Regulatory Limit
ORSGL = 14 mg/L.

Federal Regulatory Limit
The U.S. EPA has not published an MCL for ethylene glycol.

Basis for Criteria
 

The ORSGL is based on the RfD presented below and assumes that a 70 kg adult ingests 2 L/day of water. A relative source contribution factor of 20% is incorporated into the final value.

RfD: 2 mg/kg/day (U.S. EPA, 1996)
UF: 100 (10 = interspecies; 10 = intraspecies) MF: 1

Critical Effects
The RfD is based on a chronic rat oral feeding study in which rats were exposed to 50, 200, or 1000 mg/kg/day ethylene glycol. High-dosed rats had increased mortality, neutrophil count, water intake, kidney hemoglobin and hemotoxicant oral chronic nephritis. Female rats at the high dose had mild fatty changes in the liver. A NOAEL of 200 was identified from this study (U.S. EPA, 1996).

Cancer Assessment: 
D

The U.S. EPA currently classifies ethylene glycol as a group D (not classified) carcinogen (U.S. EPA, 1996).

Class
Dihydroxy alcohol

Analytical Information
PQL
: See method

Analytical Methods
Gas chromatography

PQLs and analytical methods may have been updated since this guidance value was last revised. Updated analytical methods for drinking water and their associated PQLs may be found at http://www.epa.gov/safewater/methods/methods.html.

Other Regulatory Data
Any Health Advisories, Reference Doses (RfDs), cancer assessments or Cancer Potency Factors (CPFs) referenced in this document pertain to the derivation of the current guidance value. Updated information may be obtained from the following sources:

Health Advisories - The U.S. EPA provides guidance for shorter-term exposures for chemicals based on their non-cancer effects. Current health advisories may be more current than those used to derive MCLs and may be found at http://www.epa.gov/safewater/methods/methods.html.

RfDs, cancer assessments and CPFs - For specific information pertaining to derivation of drinking water criteria, consult the Federal Register notice that announces the availability of the most current guidance for that chemical. In addition, information on other current RfDs and CPFs as well as cancer assessments for specific chemicals may be found in the U.S. EPA Integrated Risk Information System (IRIS) at http://www.epa.gov/iris/. Please note that the information in IRIS may differ from that used in the derivation process as published in the Federal Register notice.

References
U.S. EPA (U.S. Environmental Protection Agency). January 1996. Integrated Risk Information System (IRIS). Washington, D.C http://cfpub.epa.gov/ncea/iris/index.cfm.