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VINYL CHLORIDE
CASRN: 7440611

Update: March 1996

Current Massachusetts Regulatory Limit
MMCL = 0.002 mg/L. ORS has adopted the MCL published by the U.S.EPA (52 FR 25690 (7/8/87) and 56 FR 3526 (1/30/91)).

Federal Regulatory Limit
The MCL for vinyl chloride is based on its detection limit of 0.002 mg/L. The MCLG is equal to zero.

Basis for Criteria
The MCLG is set as zero based on the evidence for carcinogenic potential of a group A carcinogen. The MCL is set as close to zero as is feasible. In the case of vinyl chloride, the PQL is the limiting factor, so the MCL is set at the PQL.

Critical Effects
The critical effect from exposure to vinyl chloride is a potential increase in the incidence of cancer. In addition, high-dose exposures to vinyl chloride have produced congestion and edema of the lungs and hyperemia of the kidney and liver. Other non-cancer effects noted in acute and chronic toxicity studies include disturbances of the central nervous system, pulmonary insufficiency, cardiovascular manifestations, gastrointestinal symptoms and acroosteolysis (49 FR 24329).

Cancer Assessment: A
The U.S. EPA has classified vinyl chloride as a group A carcinogen (human) by the oral route based on the availability of sufficient evidence to support the causal association between exposure to this chemical and cancer.

Class
VOC

Analytical Information
PQL
: 0.002 mg/L

Analytical Methods
U.S. EPA 502.1; gas chromatography
U.S. EPA 503.1; gas chromatography
U.S. EPA 524.2; gas chromatography-mass spectrometry

PQLs and analytical methods may have been updated since this guidance value was last revised. Updated analytical methods for drinking water and their associated PQLs may be found at http://www.epa.gov/safewater/methods/methods.html.

Other Regulatory Data
Any Health Advisories, Reference Doses (RfDs), cancer assessments or Cancer Potency Factors (CPFs) referenced in this document pertain to the derivation of the current guidance value. Updated information may be obtained from the following sources:

Health Advisories - The U.S. EPA provides guidance for shorter-term exposures for chemicals based on their non-cancer effects. Current health advisories may be more current than those used to derive MCLs and may be found at http://www.epa.gov/waterscience/drinking/standards/dwstandards.pdf.

RfDs, cancer assessments and CPFs - For specific information pertaining to derivation of drinking water criteria, consult the Federal Register notice that announces the availability of the most current guidance for that chemical. In addition, information on other current RfDs and CPFs as well as cancer assessments for specific chemicals may be found in the U.S. EPA Integrated Risk Information System (IRIS) at http://www.epa.gov/iris/. Please note that the information in IRIS may differ from that used in the derivation process as published in the Federal Register notice.

References
Federal Register. June 12, 1984. Part V. Environmental Protection Agency. 40 CFR Part 141. National Primary Drinking Water Regulations; Volatile Synthetic Organic Chemicals; Proposed Rulemaking. (49 FR 24329).

Federal Register. July 8, 1987. Environmental Protection Agency. 40 CFR Parts 141 and 142. National Primary Drinking Water Regulations; Synthetic Organic Chemicals; Monitoring for Unregulated Contaminants; Final Rule. (52 FR 25689).

Federal Register. January 30, 1991. Part II. Environmental Protection Agency. 40 CFR Parts 141, 142, and 143. National Primary Drinking Water Regulations; Final Rule. (56 FR 3526).