- The Berkshires is the western-most county in Massachusetts, stretching north to the Vermont border and south to Connecticut. To the west is New York State, and to the east a ridge of hills over which runs the Appalachian Trail.
- Cape Cod and the Islands of Nantucket and Martha's Vineyard offer an amazing opportunity for families, professionals, and business seeking to benefit from the region's exceptional physical beauty and recreational resources.
- Central Massachusetts offers outstanding opportunities for business, families and young professionals seeking a diverse and energetic environment. Within 50 minutes of downtown Boston and anchored by the City of Worcester, the regional economy focuses on healthcare and the life sciences, professional services, manufacturing and education.
- The Greater Boston region is a unique mix of historic culture and modern change. A vibrant and diverse business sector, prestigious colleges and universities, unrivaled hospitals, world-renowned museums, rich history, and close proximity to the beaches of Cape Cod and the White and Green Mountains, are just some of the characteristics that define Greater Boston.
- MetroWest Massachusetts, comprised of 44 municipalities west of Boston in the greater Interstate 495 area, has emerged as a dynamic, economic powerhouse of significant importance to the Commonwealth.
- Northeast Massachusetts has two distinct areas, the Merrimack Valley and the North Shore. Located in Northeast Massachusetts, just 25 miles north of Boston and Cambridge, the Merrimack Valley enjoys easy access to the entire metropolitan Boston area.
- North Central Massachusetts (NCM) is comprised of 35 communities offering an array of opportunities for every industry sector. NCM is conveniently located within an hour's ride of Boston and Worcester and is served by Routes I495, 2, I190 and I290. I95 is only 25 minutes away.
- In Western Massachusetts and the Pioneer Valley, businesses are at the center of the Northeast's major markets while operating at lower costs, accessing one of the nation's leading skilled workforces and enjoying an affordable, high standard of living within urban, suburban, rural or college town settings.
- The Southeast/South coastal region is rich with history, multiculturalism, the natural beauty of seaports and parks, and a multitude of museums and tourist attractions that make the region a great place to live and work.
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