imeage for Know the signs of overdose - save a life

Naloxone – known commonly by the brand name Narcan - blocks the effects of opioids such as heroin, fentanyl, oxycodone, hydrocodone, codeine, and methadone in the brain. Opioids slow breathing, and in an overdose breathing can slow to the point of death. Giving naloxone to someone who has overdosed restores normal breathing by reversing the effects of the opioids. It is safe, easy to administer, and has no potential for abuse.

Naloxone can be administered via nasal spray (A and B) and via intramuscular injection (C and D). For more detailed information about formulations, visit Prescribe to Prevent.

Chart showing the different ways Naloxone can be administered

There are two products currently being used for nasal spray administration:

  • The first product (A) is the Adapt Pharmaceuticals 4 mg / .1 ml Narcan™ Nasal Spray.
  • The second product (B) is produced by Amphastar Pharmaceuticals links to PDF file, and is a Luer-Jet Luer Lock Prefilled Syringe of 2 mg/ 2ml naloxone hydrochloride. This is a generic formulation. This device is paired with a LMA MAD Nasal atomizer device. There is an assembly process required. During assembly, the atomizer is attached to the Luer Lock device. This allows for the intra-nasal administration of the 2 mg/2 ml naloxone hydrochloride.​

Other formulations of naloxone that you may find at your local pharmacy include:

  • EVZIO (C) is a hand-held, single-use auto-injector of .4 mg of naloxone. EVZIO is easy to administer with visual and voice instructions for guidance. EVZIO is compact in size and features a retractable needle system that helps prevent accidental needle exposure.
  • There are a number of generic products for intramuscular injection of naloxone (D). Not all available products will look like the one pictured.

More Information:


This information is provided by the Bureau of Substance Abuse Services at the Department of Public Health.