The Harm Reduction Commission was established in August 2018, with Governor Baker’s signing into law of Chapter 208 of the Acts of 2018. The Commission was charged with reviewing and making recommendations regarding harm reduction opportunities to address substance use disorder. The Commission was chaired by the Secretary of Health and Human Services, Marylou Sudders, and comprised of a diverse panel of policymakers, public health professionals, legal scholars, clinicians, and local residents. The Commission concluded its work in March 2019 with the submission of its final report to the Legislature.