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Naloxone facts and formulations

Naloxone, known commonly by the brand name NARCAN® or Kloxxado, can be administered via nasal spray, intramuscular injection, and intravenous injection.

Facts about naloxone

  • In March 1961, Dr. Jack Fishman and Dr. Mozes Lewenstein applied for one of the first patents for naloxone. In 1971, the Food and Drug Administration (FDA) approved using naloxone to treat overdoses.
  • Paramedics and hospitals have been using naloxone to reverse opioid overdoses for decades.
  • Naloxone is safe, easy to administer, has no side effects and no potential for abuse.
  • Naloxone can be administered intramuscularly, intravenously, and intranasally.
  • Naloxone has a shelf life ranging from one year to eighteen months, depending on the formulation.
  • Naloxone rescue kits from the pharmacy range in cost depending on insurance coverage.
  • Naloxone is highly effective at reversing opioid overdoses.

The different ways naloxone can be administered

A.Multi-Step Nasal Spray. Directions:Spray 1 ml (half of the syringe) into each nostril.No brand name/generic. Cost: $-$$. B. Single-Step Nasal Spray. Directions: Spray full dose into one nostril. Brand name: narcan. Cost: $$$. C. Intramuscular injection. Directions: Inject 1 ml in shoulder or thigh. No brand name/generic.Cost: $-$$. D. Auto-Injector.Directions:Use as directed by voice-prompt.Press black side firmly on outer thigh. rand name: Evzio. Cost: $$$$.Coupons available, see for more info

Please note that EVZIO may have limited availability.

For more detailed information about formulations, visit Prescribe to Prevent.