Monkeypox vaccination

What you need to know about monkeypox vaccine in Massachusetts.

Table of Contents

About the JYNNEOS vaccine

When properly administered before or soon after exposure, vaccines can help protect against monkeypox illness.

The vaccine most commonly used for preventing monkeypox infection is JYNNEOS (also known as Imvamune or Imvanex) which has been licensed by the U.S. Food and Drug Administration (FDA).

In the United States, there is a very limited supply of JYNNEOS and it is solely distributed by the Centers for Disease Control and Prevention (CDC). Massachusetts has received several allocations of vaccine from the CDC since July 5th but additional vaccine is not expected by the federal government until Fall 2022.

While the vaccine is approved as a two-dose series, given the severely limited national supply of JYNNEOS, beginning August 8, 2022 the Department of Public Health and our vaccine partners are prioritizing first doses for as many people as possible. This approach is intended to provide the broadest possible protection against the spread of monkeypox virus in Massachusetts and is consistent with a growing number of states, jurisdictions and municipalities.

Please note: As of August 8th, second dose appointments that are already scheduled will be honored and not cancelled; no new second dose appointments will be scheduled until additional vaccine is available.

People who get vaccinated should continue to protect themselves from infection by avoiding close, skin-to-skin contact, including intimate contact, with someone who has monkeypox.

Data on JYNNEOS can be found on the CDC website.

The CDC has also made available the live replicating smallpox vaccine ACAM2000. However, this vaccine has a number of characteristics that may make it unsuitable for use in the current context, including considerably greater risk to the recipient compared with JYNNEOS. Data on ACAM2000 can be found on the CDC website.

Eligibility

Vaccination will be available to individuals who live or work in Massachusetts and meet the CDC’s current eligibility criteria, prioritizing those who are most at risk of exposure to an individual with monkeypox. This includes:

  • Known contacts identified by public health via case investigation, contact tracing, and risk exposure assessments (this may include sexual partners, household contacts, and healthcare workers); as well as
  • Presumed contacts who meet the following criteria:
    • Know that a sexual partner in the past 14 days was diagnosed with monkeypox
    • Had multiple sexual partners in the past 14 days in a jurisdiction with known monkeypox

While many of the identified cases are within networks of self-identified gay and bisexual men, other men who have sex with men, and transgender individuals who have sex with men, people of any sexual orientation or gender identity can become infected and spread monkeypox.

How to obtain vaccine

JYNNEOS vaccine is available to individuals who live or work in Massachusetts and meet the CDC’s eligibility criteria. See above for eligibility details.

Administration of JYNNEOS will be by appointment only at one of the designated health care locations listed below. Healthcare providers are responsible for performing risk and exposure assessment prior to referring a patient for vaccination. Once a provider confirms vaccine eligibility, patients can make their own appointment, noting their provider determined the patient eligible for JYNNEOS.

Vaccine appointments are available from: 

  • Fenway Health (Boston): Appointments can be made by calling 617-927-6060 Monday through Friday between 9 AM and 5 PM 
  • Massachusetts General Hospital Sexual Health Clinic (Boston): Appointments can be made by calling 617-724-7000 Monday through Friday between 8:00AM and 4:30PM.
  • Boston Medical Center (Boston): Appointments can be made by calling 617-414-2803 Monday through Friday between 9 AM and 5 PM 
  • Outer Cape Cod Health Services (Provincetown): Appointments can be made by calling 508-905-2888 Monday through Friday between 8 AM and 5 PM  
  • JRI Health (Framingham)Register for an appointment directly at https://app.blockitnow.com/consumer/jricovid/npi/400000010. Appointments can also be made by calling 508-935-2960 Mondays and Fridays between 8 AM and 4 PM and Tuesday through Thursdays between 8 AM and 6:30 PM
  • Greater Lawrence Family Health Center (Lawrence): Appointments can be made by calling 978-557-2319 Monday through Friday from 8 AM to 4 PM
  • Health Innovations (Randolph): Appointments can be made by calling 339-987-1956 Monday through Friday between 10 AM and 5 PM
  • Baystate Medical Center Brightwood Health Center (Springfield): Appointments can be made by calling 413-794-4458 Monday through Friday between 8 AM and 5 PM
  • Tapestry Health (Springfield): Appointments can be made by calling 413-586-2016, extension 121, Monday through Friday between 8 AM and 4 PM
  • AIDS Project Worcester and University of Massachusetts Medical Center (Worcester): Appointments can be made by calling 508-755-3773, extension 113, Monday through Friday between 9 AM and 5 PM
  • Seven Hills Behavioral Health (New Bedford): Appointments can be made by calling 774-634-3725 Monday through Friday between 9 AM and 5 PM
  • Cambridge Health Alliance (Cambridge/Somerville): Appointments can be made by registering here: https://home.color.com/vaccine/register/metronorthmobile or by calling 781-338-0104 Monday through Friday between 9 AM and 5 PM
  • East Boston Neighborhood Health Center (Boston): Appointments can be made by calling 617-568-4500 Monday through Friday between 8 AM and 5 PM. This site also offers vaccine appointments on Saturdays between 10 AM and 2 PM
  • Codman Square Community Health Center (Dorchester): Please register for an appointment directly at https://www.codman.org/medical-service/x-clinic/. Appointments can also be made by calling 617-825-9660 Monday through Friday between 8:30 AM and 8:30 PM. This site also offers vaccine appointments on Saturday between 9 AM and 3 PM

Information for health care providers

Visit information for health care providers for details on smallpox/monkeypox vaccine (JYNNEOS™) administration, eligibility, and availability in Massachusetts. 

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