Monkeypox vaccination

What you need to know about monkeypox vaccine in Massachusetts.

Table of Contents

About the JYNNEOS vaccine

When properly administered before or soon after exposure, vaccines can help protect against monkeypox illness.

The vaccine most commonly used for preventing monkeypox infection is JYNNEOS (also known as Imvamune or Imvanex) which has been licensed by the U.S. Food and Drug Administration (FDA).

In the United States, there is a very limited supply of JYNNEOS and it is solely distributed by the Centers for Disease Control and Prevention (CDC). Massachusetts has received several allocations of vaccine from the CDC since July 5th but additional vaccine is not expected by the federal government until Fall 2022.

On August 9, CDC and FDA released an EUA (Emergency Use Authorization) allowing an alternative dose vaccination regimen in people 18 years and over and allowing the use of the JYNNEOS vaccine in individuals younger than 18 years.

The original JYNNEOS approval included the use of two 0.5 mL doses administered subcutaneously (under the skin). The alternative regimen allows the use of two lower doses, 0.1 mL of vaccine administered intradermally (into the skin). Providers administering JYNNEOS vaccine will begin utilizing this alternative dose vaccination regimen beginning August 18, 2022.

People who get vaccinated should continue to protect themselves from infection by avoiding close, skin-to-skin contact, including intimate contact, with someone who has monkeypox.

Data on JYNNEOS can be found on the CDC website.

The CDC has also made available the live replicating smallpox vaccine ACAM2000. However, this vaccine has a number of characteristics that may make it unsuitable for use in the current context, including considerably greater risk to the recipient compared with JYNNEOS. Data on ACAM2000 can be found on the CDC website.


As of October 3, 2022, vaccination will be available to individuals who live or work in Massachusetts and meet the CDC’s current eligibility criteria, which have recently expanded to include individuals at potential risk for monkeypox in addition to those with possible recent exposure to an individual with monkeypox:

Persons eligible for post-exposure vaccination (PEP) includes: 

  • Known contacts identified by public health via case investigation, contact tracing, and risk exposure assessments (this may include sexual partners, household contacts, and healthcare workers); as well as
  • Presumed contacts who meet the following criteria:
    • Know that a sexual partner in the past 14 days was diagnosed with monkeypox
    • Had multiple sexual partners in the past 14 days in a jurisdiction with known monkeypox

In addition, CDC now allows for pre-exposure vaccination (PrEP) of persons at risk for monkeypox which includes: 

  • Gay, bisexual, and other men who have sex with men, transgender, gender non-conforming, or nonbinary people who  
    • Have had a diagnosis of or have sought testing for one or more sexually transmitted diseases (i.e., chancroid, chlamydia, gonorrhea, or syphilis) in the past year 
    • Are living with HIV infection 
    • Are on or are eligible to be on HIV PrEP 
    • Have recently had more than one sex partner 
  • People who:
    • Have had sex at a private or commercial sex venue (e.g., sex party, bathhouse) 
    • Have had sex in association with a large public event (e.g., rave, circuit party) in a geographic area where monkeypox transmission is occurring 
  • Sexual partners of people with the above risks 
  • People who anticipate experiencing the above risks 

When you request vaccine, you will not be asked which of these criteria applies to you. It is sufficient to say that you consider yourself to be at risk for monkeypox. 

While many of the identified cases are within networks of self-identified gay and bisexual men, other men who have sex with men, and transgender individuals who have sex with men, people of any sexual orientation or gender identity can become infected and spread monkeypox. 

How to obtain vaccine

JYNNEOS vaccine is available to individuals who live or work in Massachusetts and meet the CDC’s eligibility criteria. See above for eligibility details.

Administration of JYNNEOS is available at any one of the designated health care locations listed below. Healthcare providers are responsible to perform exposure assessment to confirm eligibility prior to scheduling an appointment for a vaccine. Vaccination sites designated below may also offer vaccination on a walk-in basis (no appointment required).

Please contact sites first to confirm that walk-in vaccinations are offered.

Vaccine appointments are available from:



For appointments

Boston Boston Medical Center Register for an appointment directly at or call 617-414-2803 Monday through Friday between 9 AM and 5 PM.
Boston Codman Square Health Center (Dorchester)

Call 617-822-8271 Monday through Friday between 8:30 AM and 8:30 PM. This site offers vaccine appointments Monday through Friday between 8:30 AM to 5 PM and Saturday 9 AM to 1 PM at its 637 Washington Street location in Dorchester.

Walk-in appointments:

Monday through Friday, 9 AM – 4 PM

Codman Square Health Center
637 Washington Street, Dorchester, MA 02124

Please check in at the main reception desk to be directed to the correct department.
Boston East Boston Neighborhood Health Center Call 617-568-4500 Monday through Friday between 8 AM and 5 PM. This site also offers vaccine appointments on Saturdays between 10 AM and 2 PM.
Boston Fenway Health 

Call 617-927-6060 Monday through Friday between 9 AM and 5 PM.

Walk-in appointments:

Tuesday through Thursday 10 AM - 12 PM and 1 PM - 3 PM

Fenway Health – Boston
10th Floor, 1340 Boylston Street, Boston, MA, 02215


Health Innovations (Chelsea/Randolph)

Appointments for first and second doses can be made online at or call 339-987-1956 Tuesday through Friday between 10 AM and 5 PM.

Walk-in appointments:

Tuesdays, 11 AM - 5 PM
Health Innovations - Chelsea
100 Everett Ave., Suite 3B, Chelsea, MA 02150

Thursdays, 12 PM - 7 PM and Fridays, 11 AM - 5 PM
Health Innovations - Randolph
1193 North Main St., Randolph, MA 02368 (Rear Entrance)

For more information on upcoming events, please visit
Boston Massachusetts General Hospital Sexual Health Clinic Call 617-724-7000 Monday through Friday between 8:00 AM and 4:30 PM.
Cambridge Health Alliance Register online at or call 781-338-0104 Monday through Friday between 9 AM and 5 PM.
Cape Cod Outer Cape Cod Health Services (Provincetown) Call 508-905-2888 Monday through Friday between 8 AM and 5 PM.
Central AIDS Project Worcester and University of Massachusetts Medical Center (Worcester)

Register online at or call 508-755-3773, extension 113, Monday through Friday between 9 AM and 5 PM.

Walk-in appointments:

Tuesday through Friday, 9 AM – 5 PM

(No appointment available during lunch 12 PM - 1 PM)

AIDS Project Worcester
165 Southbridge Street, Worcester, MA 01608

JRI Health (Framingham)

Register for an appointment online at or call 508-935-2960 Mondays and Fridays between 8 AM and 4 PM and Tuesday through Thursdays between 8 AM and 6:30 PM.

Walk-in appointments:

Monday through Friday, 9 AM to 3 PM
Program RISE 1
1 Grant Street, Suite 100, Framingham, MA 01702

Learn more:

Please call 508-935-2960 to first to ensure the nurse is available. Services are offered in English, Spanish, and Portuguese.
Northeast Greater Lawrence Family Health Center (Lawrence) Call 978-557-2319 Monday through Friday from 8 AM to 4 PM.
Southeast Seven Hills Behavioral Health (New Bedford)

Call 774-634-3725 Monday through Friday between 9 AM and 5 PM.

Walk-in appointments:

Monday through Friday, 9:30 AM – 4 PM
1177 Acushnet Avenue, New Bedford, MA 02746

For more information, contact 774-634-3725.
Western Baystate Medical Center Brightwood Health Center (Springfield) Call 413-794-4458 Monday through Friday between 8 AM and 5 PM.

Tapestry Health (Springfield)

Call 413-586-2016, extension 121, Monday through Friday between 8 AM and 4 PM.

Walk-in appointments:

Tuesday through Friday, 10 AM - 11:30 AM and 1 PM - 3:30 PM
1985 Main Street, Springfield, MA 01103

To verify drop-in hours, call the scheduling line at 413-586-2016 x 121.

Information for health care providers

Visit information for health care providers for details on smallpox/monkeypox vaccine (JYNNEOS™) administration, eligibility, and availability in Massachusetts.