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Information for providers about therapeutic treatments for COVID-19

A large percentage of all Massachusetts residents may be eligible for therapeutics to treat early mild-to-moderate COVID-19. Note that treatment should begin as soon as possible after diagnosis of COVID.

Massachusetts has been working hard to improve its ability to treat COVID-19. We are grateful for the support of our healthcare partners in caring for people across the state. Hospitals and healthcare providers have successfully included COVID-19 treatments in their patient care plans. This ensures that our healthcare system can continue to provide important services, including giving remdesivir and providing oral antiviral therapy.

Table of Contents


The U.S. Food and Drug Administration (FDA) has approved or issued emergency use authorizations (EUA) for therapeutics for treatment of early mild-to-moderate COVID-19 in high-risk patients:

  • The preferred agent at this time is the oral antiviral nirmatrelvir boosted with ritonavir (PAXLOVID) begun within 5 days of symptom onset. 
  • Similar effectiveness can be achieved with the intravenous antiviral remdesivir (VEKLURY) which requires infusion on 3 consecutive days and must be started within 7 days of symptom onset.
  • If neither of these therapeutics is available or appropriate, the oral medication molnupiravir may be given starting within 5 days of symptom onset.

Five previously authorized monoclonal antibodies are no longer authorized due to the presence of variants that reduce their effectiveness: Casirivimab/imdevimab (REGEN-COV)Bamlanivimab/etesevimabSotrovimab, Bebtelovimab, and Evusheld.

Use of antiviral IV therapy or oral antiviral medications is not a substitute for vaccination against COVID-19. Everyone is still encouraged to stay up to date with COVID-19 vaccinations.

FDA shelf-life extension

There have been recent changes in shelf-life extensions for several therapeutics. Please be sure to always check the FDA website for the most up to date and product-specific expiration dates. In most cases, the packaging labels do not represent the most current expiration date for that product. 



  • FDA-approved oral antivirals are widely available via retail pharmacies across the Commonwealth.
  • COVID-19 treatments should be considered for all your patients and given to all patients appropriate for treatment.
    • This group includes a large percentage of all MA residents eligible due to heart, lung, liver, or kidney disease, diabetes, pregnancy, dementia, cancer, disability, substance use disorder, mental health disorder, age over 65, overweight/obesity and immunocompromised. View the full CDC list of medical conditions
  • PAXCESS Patient Support Program: The U.S. Government (USG) has launched the PAXCESS Patient Support Program to provide cost savings options for individuals who have been prescribed Paxlovid. This program offers two options for patients:  
    • Pfizer PAXCESS Co-Pay Savings Program for commercially insured individuals and takes just a few minutes to access a copay card online
    • The USG Patient Assistance Program (USG PAP - Operated by Pfizer) is available for individuals with Medicare, Medicaid, TRICARE, VA Community Care Network as well as uninsured patients.  This can also be accessed by phone: 1-877-C19-PACK (1-877-219-7225) for IVR (interactive voice response) and Live Operator Support. 
  • Telehealth is available for individuals 12 or older living in Massachusetts who test  positive for COVID-19 and are experiencing symptoms. This telehealth service can determine if Paxlovid may be an option. If it is, pickup at a pharmacy or free overnight delivery is available. More at mass.gov/CovidTelehealth.
    • This telehealth program will continue at least through June 30, 2024. 

Additionally, hospitals and other healthcare providers throughout Massachusetts serve as sites for distribution of COVID-19 therapeutics and will administer remdesivir and dispense oral antiviral therapy. 

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